United States securities and exchange commission logo

                          June 15, 2023

       Dale Sander
       Chief Financial Officer
       Humacyte, Inc.
       2525 East North Carolina Highway 54
       Durham, NC 27713

                                                        Re: Humacyte, Inc.
Statement on Form S-3
                                                            Filed June 9, 2023
                                                            File No. 333-272550

       Dear Dale Sander:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Alan
Campbell at 202-551-4224 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Kerry S. Burke