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  <xs:element id="huma_HumacyteIncMember" abstract="true" name="HumacyteIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DebtInstrumentUnusedBorrowingCapacityAmountPerTranche" abstract="false" name="DebtInstrumentUnusedBorrowingCapacityAmountPerTranche" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="huma_SiliconValleyBankAndSVBInnovationCreditFundVIIILPMember" abstract="true" name="SiliconValleyBankAndSVBInnovationCreditFundVIIILPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlans" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="huma_CollaborativeArrangementMilestonePaymentsDomain" abstract="true" name="CollaborativeArrangementMilestonePaymentsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_WarrantsAndRightsOutstandingPolicyPolicyTextBlock" abstract="false" name="WarrantsAndRightsOutstandingPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="huma_StockIssuedDuringPeriodSharesReverseRecapitalization" abstract="false" name="StockIssuedDuringPeriodSharesReverseRecapitalization" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_RoyaltyPercentageOfAnnualNetSalesPayable" abstract="false" name="RoyaltyPercentageOfAnnualNetSalesPayable" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="huma_DecellularizedTissueEngineeringPatentRightsMember" abstract="true" name="DecellularizedTissueEngineeringPatentRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DebtInstrumentPrepaymentFeePercent" abstract="false" name="DebtInstrumentPrepaymentFeePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="huma_StockOptionPlan2005Member" abstract="true" name="StockOptionPlan2005Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_TubularProsthesesPatentRightsMember" abstract="true" name="TubularProsthesesPatentRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_LicenseAgreementMember" abstract="true" name="LicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_CollaborativeArrangementSharesIssued" abstract="false" name="CollaborativeArrangementSharesIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_FreseniusMedicalCareMember" abstract="true" name="FreseniusMedicalCareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche" abstract="false" name="ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_AggregateMilestonePaymentsPotentiallyReceivable" abstract="false" name="AggregateMilestonePaymentsPotentiallyReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
