<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:83c0dc25-1242-41f0-bbe3-519831e8ce91,g:abfb93ca-696e-46d4-8c73-026ac3876822-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="huma-20220331.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_a6f6d818-8b2f-42af-9705-6a1d279660f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_23734a13-711d-4b51-82d5-f272dcda264a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_a6f6d818-8b2f-42af-9705-6a1d279660f5" xlink:to="loc_us-gaap_Liabilities_23734a13-711d-4b51-82d5-f272dcda264a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_c5a46a4c-1830-42c0-9fe7-a82ed38496da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_a6f6d818-8b2f-42af-9705-6a1d279660f5" xlink:to="loc_us-gaap_CommitmentsAndContingencies_c5a46a4c-1830-42c0-9fe7-a82ed38496da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f14b2b3b-5cfb-41d2-80e2-3306ab3c5807" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_a6f6d818-8b2f-42af-9705-6a1d279660f5" xlink:to="loc_us-gaap_StockholdersEquity_f14b2b3b-5cfb-41d2-80e2-3306ab3c5807" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_5f95765e-de57-43a4-a919-949deed4e318" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_885cd8df-cb9f-48d2-bc7f-a67f293ae1ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_5f95765e-de57-43a4-a919-949deed4e318" xlink:to="loc_us-gaap_LiabilitiesCurrent_885cd8df-cb9f-48d2-bc7f-a67f293ae1ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_85244857-d169-4833-b62c-2c7ddcb6a845" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_5f95765e-de57-43a4-a919-949deed4e318" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_85244857-d169-4833-b62c-2c7ddcb6a845" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_5514f32a-02b3-43be-853a-c326de879ead" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_5f95765e-de57-43a4-a919-949deed4e318" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_5514f32a-02b3-43be-853a-c326de879ead" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_836e8515-616b-43ce-a8e8-6282b2a8afe2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_5f95765e-de57-43a4-a919-949deed4e318" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_836e8515-616b-43ce-a8e8-6282b2a8afe2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a4514a7c-0bea-42e6-82ce-4f13b2886381" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_5f95765e-de57-43a4-a919-949deed4e318" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a4514a7c-0bea-42e6-82ce-4f13b2886381" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredLongTermDebt_5e80de37-89e5-481e-851c-650134dd931e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuredLongTermDebt"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_5f95765e-de57-43a4-a919-949deed4e318" xlink:to="loc_us-gaap_SecuredLongTermDebt_5e80de37-89e5-481e-851c-650134dd931e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_f8f54f7b-2864-485d-9a3f-d86653025c40" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_06f40b66-4357-48db-90b5-d13cfb7371b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8f54f7b-2864-485d-9a3f-d86653025c40" xlink:to="loc_us-gaap_AccountsPayableCurrent_06f40b66-4357-48db-90b5-d13cfb7371b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_8899d123-eaa9-4d68-ae13-65a81e1228ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8f54f7b-2864-485d-9a3f-d86653025c40" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_8899d123-eaa9-4d68-ae13-65a81e1228ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_7837aca0-4433-4b29-ab5f-f5a637c320a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8f54f7b-2864-485d-9a3f-d86653025c40" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_7837aca0-4433-4b29-ab5f-f5a637c320a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedPayrollTaxesCurrent_eb801378-e355-49f3-96d7-0f1f7da9cda6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedPayrollTaxesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8f54f7b-2864-485d-9a3f-d86653025c40" xlink:to="loc_us-gaap_AccruedPayrollTaxesCurrent_eb801378-e355-49f3-96d7-0f1f7da9cda6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_ee32125f-b028-4fbb-b660-4074de5b557a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8f54f7b-2864-485d-9a3f-d86653025c40" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_ee32125f-b028-4fbb-b660-4074de5b557a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_e320c355-e98b-4f4d-a4f5-0387d3f8ba39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_e2151da3-a383-496e-8402-cb47591e6e7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_e320c355-e98b-4f4d-a4f5-0387d3f8ba39" xlink:to="loc_us-gaap_PreferredStockValue_e2151da3-a383-496e-8402-cb47591e6e7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c738d228-6ee7-4050-bcba-9d19f53fe329" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_e320c355-e98b-4f4d-a4f5-0387d3f8ba39" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c738d228-6ee7-4050-bcba-9d19f53fe329" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_ad18c720-5b67-4fa6-bba9-4ee5362008f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_e320c355-e98b-4f4d-a4f5-0387d3f8ba39" xlink:to="loc_us-gaap_AdditionalPaidInCapital_ad18c720-5b67-4fa6-bba9-4ee5362008f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_d3a5d3ed-4ddc-4991-bf32-b312182304ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_e320c355-e98b-4f4d-a4f5-0387d3f8ba39" xlink:to="loc_us-gaap_CommonStockValue_d3a5d3ed-4ddc-4991-bf32-b312182304ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_7ea733df-4666-414e-8770-411d58731922" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_ea5af997-000e-4107-a3c9-5b4bf1131c5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7ea733df-4666-414e-8770-411d58731922" xlink:to="loc_us-gaap_AssetsCurrent_ea5af997-000e-4107-a3c9-5b4bf1131c5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_9ede27a1-cf91-4eab-98be-27c252ea0ddc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7ea733df-4666-414e-8770-411d58731922" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_9ede27a1-cf91-4eab-98be-27c252ea0ddc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_a05b0445-990d-4b5e-8e10-7211a2e0f6af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7ea733df-4666-414e-8770-411d58731922" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_a05b0445-990d-4b5e-8e10-7211a2e0f6af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_4be45d45-879c-42d3-b52f-9d7b6d856615" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_7ea733df-4666-414e-8770-411d58731922" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_4be45d45-879c-42d3-b52f-9d7b6d856615" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_a61fed0a-ae00-4f2f-821d-d4292cf65ac1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_40d005c4-5f7f-40ee-bf3f-5cd07d73267e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a61fed0a-ae00-4f2f-821d-d4292cf65ac1" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_40d005c4-5f7f-40ee-bf3f-5cd07d73267e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_eaa38124-a8bf-4146-8ca7-27046d9c4993" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a61fed0a-ae00-4f2f-821d-d4292cf65ac1" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_eaa38124-a8bf-4146-8ca7-27046d9c4993" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_d1205ac9-3902-4d6b-919b-a2b894cf7b2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a61fed0a-ae00-4f2f-821d-d4292cf65ac1" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_d1205ac9-3902-4d6b-919b-a2b894cf7b2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_f72dd949-babd-4ae4-a7ab-85b5ce9be668" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a61fed0a-ae00-4f2f-821d-d4292cf65ac1" xlink:to="loc_us-gaap_ShortTermInvestments_f72dd949-babd-4ae4-a7ab-85b5ce9be668" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="huma-20220331.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_42e169f1-dad2-40e7-9402-9a413cf5c083" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_36af3346-b6fa-46bb-b9b7-8ad256cbca11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_42e169f1-dad2-40e7-9402-9a413cf5c083" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_36af3346-b6fa-46bb-b9b7-8ad256cbca11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_9055dd4b-8b7f-4312-a437-a5bf245e9a4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_42e169f1-dad2-40e7-9402-9a413cf5c083" xlink:to="loc_us-gaap_OperatingIncomeLoss_9055dd4b-8b7f-4312-a437-a5bf245e9a4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ddf5f0c2-ec7a-464b-ae84-9c70785f39fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_ac725324-0af6-4df4-8dba-8f38673e65c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ddf5f0c2-ec7a-464b-ae84-9c70785f39fd" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_ac725324-0af6-4df4-8dba-8f38673e65c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_631dae26-242b-48f4-996e-534b1c187255" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ddf5f0c2-ec7a-464b-ae84-9c70785f39fd" xlink:to="loc_us-gaap_OperatingExpenses_631dae26-242b-48f4-996e-534b1c187255" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_2ba0d8f7-8d2b-43d9-95d7-7c251e687b73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_55a4d31f-5559-411b-9ae8-4962b176b8ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2ba0d8f7-8d2b-43d9-95d7-7c251e687b73" xlink:to="loc_us-gaap_InterestExpense_55a4d31f-5559-411b-9ae8-4962b176b8ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_bb757003-585c-4bf5-ad5d-9f48c5ff6f6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2ba0d8f7-8d2b-43d9-95d7-7c251e687b73" xlink:to="loc_us-gaap_InvestmentIncomeInterest_bb757003-585c-4bf5-ad5d-9f48c5ff6f6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_64cf7c6a-9c81-41fc-bc87-7d35985244f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2ba0d8f7-8d2b-43d9-95d7-7c251e687b73" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_64cf7c6a-9c81-41fc-bc87-7d35985244f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_b9396c17-0e38-4763-bddb-6debffb0bb80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2ba0d8f7-8d2b-43d9-95d7-7c251e687b73" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_b9396c17-0e38-4763-bddb-6debffb0bb80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_9a62b56e-4903-45bc-9416-ed2070f8d2bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_fd865dcf-8032-46c8-a230-7728226d86a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_9a62b56e-4903-45bc-9416-ed2070f8d2bd" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_fd865dcf-8032-46c8-a230-7728226d86a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_d5a6e5cf-1378-4724-aa28-9c35f218757d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_9a62b56e-4903-45bc-9416-ed2070f8d2bd" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_d5a6e5cf-1378-4724-aa28-9c35f218757d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_81b1c141-51ff-41fc-8f0b-75560038e00b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_f91a47ac-ff3a-4591-aca1-02ec10d8cc7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_81b1c141-51ff-41fc-8f0b-75560038e00b" xlink:to="loc_us-gaap_OperatingIncomeLoss_f91a47ac-ff3a-4591-aca1-02ec10d8cc7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_dcc156fe-fef3-48a7-897c-d2e5ff7ccb15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_81b1c141-51ff-41fc-8f0b-75560038e00b" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_dcc156fe-fef3-48a7-897c-d2e5ff7ccb15" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="huma-20220331.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_64862109-235a-47d9-a5b4-7c111a43a856" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_707e6c27-3367-4edb-89f1-42d45c8fbee1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_64862109-235a-47d9-a5b4-7c111a43a856" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_707e6c27-3367-4edb-89f1-42d45c8fbee1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e640b6b3-28b3-46d6-8fac-e1170b2eb566" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_21bef3a3-1ac1-455f-99b5-cc9940e9c95e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e640b6b3-28b3-46d6-8fac-e1170b2eb566" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_21bef3a3-1ac1-455f-99b5-cc9940e9c95e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7b754148-c2cc-4a83-995a-40638997d6f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e640b6b3-28b3-46d6-8fac-e1170b2eb566" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7b754148-c2cc-4a83-995a-40638997d6f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_84c7ef2d-c955-47ef-9727-4d9cff5bbc27" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e640b6b3-28b3-46d6-8fac-e1170b2eb566" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_84c7ef2d-c955-47ef-9727-4d9cff5bbc27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_93b185ad-a3e0-474d-8319-c87115a8a9cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_93b185ad-a3e0-474d-8319-c87115a8a9cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_fff85dbe-5778-4727-a7cc-c2b91ed8a0c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_fff85dbe-5778-4727-a7cc-c2b91ed8a0c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d3b8eec3-d4b7-40c6-bf13-ac54f567a8be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_NetIncomeLoss_d3b8eec3-d4b7-40c6-bf13-ac54f567a8be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_bc0b74d7-62e5-4d56-9b6e-48437fd22f6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_bc0b74d7-62e5-4d56-9b6e-48437fd22f6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_a8b6b5d3-7d5a-4fc1-81ec-5c38402d7487" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_a8b6b5d3-7d5a-4fc1-81ec-5c38402d7487" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_a1e079ef-a537-4286-8a47-83cb57f9bf2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_a1e079ef-a537-4286-8a47-83cb57f9bf2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_14df18dc-663a-4f88-97fb-3c5f5cc6aa11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_14df18dc-663a-4f88-97fb-3c5f5cc6aa11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_00386596-274b-426d-a02c-56fccc012c3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_00386596-274b-426d-a02c-56fccc012c3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_c6bc5ef9-7809-434a-90bd-a9d50c5a00e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_c6bc5ef9-7809-434a-90bd-a9d50c5a00e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_dac31a0c-bcaa-4f86-9f46-63341fb7d168" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_dac31a0c-bcaa-4f86-9f46-63341fb7d168" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_1dbbfa30-fbb0-4bb9-857b-1c0694ed1ddb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_Depreciation_1dbbfa30-fbb0-4bb9-857b-1c0694ed1ddb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_f8b5073a-a7c8-4622-9bc8-0467c15bc7dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_f8b5073a-a7c8-4622-9bc8-0467c15bc7dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_83419a30-fed2-46fc-8d52-bc8a58461cf0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_83419a30-fed2-46fc-8d52-bc8a58461cf0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_110ce0a3-5180-4ca1-afc2-b7fa0724594b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6746655a-ece4-45e2-a344-3acbc19db272" xlink:to="loc_us-gaap_ShareBasedCompensation_110ce0a3-5180-4ca1-afc2-b7fa0724594b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f5ecb710-ba67-4d7e-9abd-5b361cdf1cf1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromBankDebt_5fed834e-f8ba-4536-8e23-5d9f43abf030" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromBankDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f5ecb710-ba67-4d7e-9abd-5b361cdf1cf1" xlink:to="loc_us-gaap_ProceedsFromBankDebt_5fed834e-f8ba-4536-8e23-5d9f43abf030" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_a3da9854-1f1e-484d-a8f3-599670a57c56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f5ecb710-ba67-4d7e-9abd-5b361cdf1cf1" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_a3da9854-1f1e-484d-a8f3-599670a57c56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_1d21f2e4-35e3-4bf3-822b-b1af1f273752" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f5ecb710-ba67-4d7e-9abd-5b361cdf1cf1" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_1d21f2e4-35e3-4bf3-822b-b1af1f273752" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_1eaab2c4-352b-4eca-b6c0-32dfe27d7812" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f5ecb710-ba67-4d7e-9abd-5b361cdf1cf1" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_1eaab2c4-352b-4eca-b6c0-32dfe27d7812" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="huma-20220331.xsd#FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_8392ac9d-3f7c-4f44-b9fe-33de76329e0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_95ef52dc-c658-472b-8278-3ab78357955f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_8392ac9d-3f7c-4f44-b9fe-33de76329e0b" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_95ef52dc-c658-472b-8278-3ab78357955f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_587f6d4f-e364-4e15-bb71-014bca974437" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_8392ac9d-3f7c-4f44-b9fe-33de76329e0b" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_587f6d4f-e364-4e15-bb71-014bca974437" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_f5614817-e2c9-4d0e-b09d-692e5bc4dfde" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_f02247ee-aa63-4cbb-bf4c-d6d29facb3be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_f5614817-e2c9-4d0e-b09d-692e5bc4dfde" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_f02247ee-aa63-4cbb-bf4c-d6d29facb3be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_375404dc-fa54-4b88-9ba6-a981dbaf300b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_f5614817-e2c9-4d0e-b09d-692e5bc4dfde" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_375404dc-fa54-4b88-9ba6-a981dbaf300b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/PropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="huma-20220331.xsd#PropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/PropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_d463075c-c5e9-46b1-b15d-1ac74b473302" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_723d4152-321c-4222-b49b-37749844448a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_d463075c-c5e9-46b1-b15d-1ac74b473302" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_723d4152-321c-4222-b49b-37749844448a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_164c1aeb-c5bf-468b-aee3-56d02b308466" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_d463075c-c5e9-46b1-b15d-1ac74b473302" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_164c1aeb-c5bf-468b-aee3-56d02b308466" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/AccruedExpensesDetails" xlink:type="simple" xlink:href="huma-20220331.xsd#AccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/AccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_05352c83-4431-4d4f-8668-f0221b1f75e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent_14ea295f-3a7d-40f1-84fb-0936245b349b" xlink:href="huma-20220331.xsd#huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_05352c83-4431-4d4f-8668-f0221b1f75e4" xlink:to="loc_huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent_14ea295f-3a7d-40f1-84fb-0936245b349b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_c5e65ea6-ed73-4044-82f7-070e42cc7e50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_05352c83-4431-4d4f-8668-f0221b1f75e4" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_c5e65ea6-ed73-4044-82f7-070e42cc7e50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_35d96cb3-5acc-4731-b3c9-52e09b95d487" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_05352c83-4431-4d4f-8668-f0221b1f75e4" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_35d96cb3-5acc-4731-b3c9-52e09b95d487" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails" xlink:type="simple" xlink:href="huma-20220331.xsd#DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_f6a4c510-e996-4e89-829f-3930bcd86cd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_52ebeeae-7c62-429b-b4b9-c54a1f04b659" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_f6a4c510-e996-4e89-829f-3930bcd86cd6" xlink:to="loc_us-gaap_LongTermDebtCurrent_52ebeeae-7c62-429b-b4b9-c54a1f04b659" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_391ad5fe-e894-4776-bcc3-b528c741e804" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_f6a4c510-e996-4e89-829f-3930bcd86cd6" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_391ad5fe-e894-4776-bcc3-b528c741e804" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails_1" xlink:type="simple" xlink:href="huma-20220331.xsd#DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails_1"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_47ddeb17-ee56-4029-9e18-c12a065d0a16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_2230df3f-38c4-4180-84ed-7798e499bf5e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_47ddeb17-ee56-4029-9e18-c12a065d0a16" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_2230df3f-38c4-4180-84ed-7798e499bf5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentFinalPaymentAmount_43fb47d4-d6da-436e-9a7d-f43f922c5bb9" xlink:href="huma-20220331.xsd#huma_DebtInstrumentFinalPaymentAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_47ddeb17-ee56-4029-9e18-c12a065d0a16" xlink:to="loc_huma_DebtInstrumentFinalPaymentAmount_43fb47d4-d6da-436e-9a7d-f43f922c5bb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_c8e24ff8-f576-4503-b291-1e9a654855f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_47ddeb17-ee56-4029-9e18-c12a065d0a16" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_c8e24ff8-f576-4503-b291-1e9a654855f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtFutureMinimumPaymentsofPrincipalDetails" xlink:type="simple" xlink:href="huma-20220331.xsd#DebtFutureMinimumPaymentsofPrincipalDetails"/>
  <link:calculationLink xlink:role="http://www.humacyte.com/role/DebtFutureMinimumPaymentsofPrincipalDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_0f728887-5b9f-4b06-947a-17c8b43299eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_f568ba1c-1750-4aad-b717-609ba8b39ba5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0f728887-5b9f-4b06-947a-17c8b43299eb" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_f568ba1c-1750-4aad-b717-609ba8b39ba5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_fdb02fd4-16a4-4248-be0a-9056df0e583d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0f728887-5b9f-4b06-947a-17c8b43299eb" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_fdb02fd4-16a4-4248-be0a-9056df0e583d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_c7c68aaf-838a-45ef-b6cc-e9ea3abab644" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0f728887-5b9f-4b06-947a-17c8b43299eb" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_c7c68aaf-838a-45ef-b6cc-e9ea3abab644" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_089ed748-fe85-4065-822c-d7fa7e1bf418" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0f728887-5b9f-4b06-947a-17c8b43299eb" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_089ed748-fe85-4065-822c-d7fa7e1bf418" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
